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Molecular Toxicology

This module is focussed on understanding mechanisms of toxicity at the molecular level. In a number of lectures and case-studies, molecular mechanisms underlying (organ-selective) toxicity and carcinogenicity will be discussed. Special emphasis will be on the role of drug metabolism and bio(in)activation in toxicology. Topics include: multiplicity and properties of drug-metabolising enzymes (cytochrome P450, glutathione S-transferases and others); experimental approaches to characterize enzymes involved in drug metabolism; clinical and toxicological consequences of genetic polymorphisms of drug metabolising enzymes; chemical and biological properties of reactive intermediates responsible for toxicity; mechanisms underlying idiosyncratic drug reactions; novel computational approaches to predict drug metabolism and toxicity; and, mechanisms determining organ-selective toxicity. Participants should have a sound knowledge of basic organic chemistry to be able to fully profit from this course.

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